If you have been experiencing vaginal dryness, you know how difficult it can be to live with symptoms like daily discomfort and painful sex. Replens is a safe, estrogen-free, over-the-counter vaginal moisturizer that has been clinically shown to address vaginal dryness symptoms. Replens goes to work immediately to sooth dry vaginal tissues and replenish moisture for up to 5 days. Gynecologists frequently recommend Replens as an alternative to prescription hormone therapy.